VESIsorb®
VESIsorb® is a unique patented delivery system to improve the absorption and bioavailability of poorly water soluble natural ingredients and bio-actives.
PRODUCT INFORMATION
VESIsorb® formulations delivering optimal bioavailability of natural science-backed ingredients include CoQ10, QH Ubiquinol, Omega-3, Curcumin, Krill Oil, Vitamin D-3 and proprietary product formulas such as Brain Pro Sport 3.0®, OmegaKrill™ 5X , and Ultimate Red Yeast Rice™ . Applications include capsule dosage forms, drink mixes, stick packs, functional food and beverage products, gummies and more.
THE VESISORB® DELIVERY SYSTEM
The #1 World Wide Patent-Protected Deliver System
Developed by Vesifact, Baar, Switzerland, the innovative VESIsorb® delivery system brings “Swiss Precision” to our advanced and patent-protected delivery system platform.
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BIO-ACTIVE BIOAVAILABILITY
The improvement of oral drug or natural bio-active bioavailability by this technology is broken down into three steps:
STEP 1
Formation of the colloidal delivery system. When mixed with an aqueous system (such as the GI-Lumen), this unique lipid-based formulation naturally forms a self-assembling colloidal delivery system containing solubilized bioactives. A colloidal droplet is typically less than 100nm in diameter and consists of a monolayer with the CoCo10 or other bioactives within its oil core.
STEP 2
Diffusion of the solubilized bioactives across the unstirred water layer.
STEP 3
Transfer of the solubilized CoQ10 or other bioactives to the absorptive surface of the intestine.
LATEST CLINICAL STUDIES

The peer-reviewed journal, “Alternative Therapies in Health and Medicine,” recently published the results of a double-blind study comparing the bioavailability of patented CoQsource® (coenzyme Q10 in a VESIsorb® formulation) Bio-Enhanced CoQ10 to that of other bio-enhanced formulations. The study, entitled, “Relative Bioavailability Comparison of Different Coenzyme Q10 Formulations with a Novel Delivery System,” appears in the March/April, 2009 issue, Volume 15, Number 2.

The graph below provides a vivid illustration of the difference in CoQsource® (the orange line) which is coenzyme Q10 in the VESIsorb® delivery system versus the three other “bio-enhanced” coenzyme Q10 products in plasma concentration levels over time. CoQsource® (coenzyme Q10 in the VESIsorb® delivery system) not only has higher plasma concentration levels after one hour, but continues to increase dramatically before reaching Cmax at about 4 hours. The plasma concentration of CoQsource® remains well above levels for the 3 other treatments throughout the 24 hour period.

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PRODUCT APPLICATION
The patented VESIsorb® delivery system is a naturally self-assembling colloidal droplet delivery system that has been clinically proven to increase absorption of nutritional supplement, functional food & beverage and cosmetic ingredients.
Product Advantages
  • The advantages of VESIsorb® delivery system go well beyond absorption and bioavailability.
  • The VESIsorb® system broadens the applications for certain bio-actives into food products, drink mixes, functional beverages and cosmetics.
  • The VESIsorb® system is easy to work with in production and effectively improves many production systems.
  • VESIsorb® has succeeded in addressing issues such as improved water solubility, oxidative stability, shelf life and uniformity of dispersion in the delivery medium.
THE DIFFERENCE BETWEEN MICELLES, LIPOSOMES AND VESISORB® COLLOIDAL DROPLETS
VESIsorb® vs. Micelles
Micelles are composed of a surfactant or surfactant mixture and the active substance to be solubilized within the center of the micelle. Compared to a micellar system, the VESIsorb® system contains lower amounts of surfactant (which is highly desirable) and high amounts of oil (lipophilic core/center where the active substance is dissolved) which is a significant advantage.
VESIsorb® vs. Liposomes
Liposomes are vesicles and composed of a phospholipid bi-layer membrane surrounding an aqueous core. Fat-soluble active substances can only be solubilized within the bi-layer membrane, thus the loading capacity is limited and lower compared to VESIsorb®.
VESIsorb® IS DESCRIBED AS A TECHNOLOGICALLY - ADVANCED DELIVERY SYSTEM
The colloidal droplet system is customized to each active or combinations of actives. Successful VESIsorb® formulations are optimized for droplet conversion performance using dynamic light scattering analysis.

The goal is 100% solubilized actives, in a completely homogeneous system with mean droplet size of less than 100nm. Meeting these criteria confirms that the VESIsorb® self-assembling colloidal droplet system is working.

What is also important to understand is that the system is not only built around the unique molecular characteristics of the bio-active but designed for optimal performance in the body.

The following photos are a VESIsorb® Coenzyme Q10 formulation compared to a leading brand that claimed the product was formulated for improved absorption: